A subvariant of the omicron COVID, BA.4.6, which has been quickly gaining traction in the US, is now confirmed to be spreading in the UK.
The latest briefing document on covid variant from the UK Health Security Agency (UKHSA) noted that during the week beginning August 14, BA.4.6 accounted for 3.3 per cent of samples in the UK. Similarly, according to the Centre’s for Disease Control and Prevention, BA.4.6 now accounts for more than 9 per cent of recent cases across the US. The variant has also been identified in several other countries around the world.
Detail About BA.4.6, Should we have to worry about this new Variant
BA.4.6 is a descendant of the BA.4 variant of omicron. BA.4 was first detected in January 2022 in South Africa and has since spread around the world alongside the BA.5 variant.
It is not entirely clear how BA.4.6 has emerged, but it’s possible it could be a recombinant variant. While BA.4.6 will be similar to BA.4 in many ways, it carries a mutation to the spike protein, a protein on the surface of the virus which allows it to enter our cells.
This mutation, R346T, has been seen in other variants and is associated with immune evasion, meaning it helps the virus to escape antibodies acquired from vaccination and prior infection. Fortunately, omicron infections generally cause less serious illness, and we’ve seen fewer deaths with omicron than with earlier variants. Indeed, there have been no reports yet that this variant is causing more severe symptoms. BA.4.6 appears to be even better at evading the immune system than BA.5, the currently dominant variant. Although this information is based on a preprint (a study that is yet to be peer-reviewed), other emerging data supports this.
The University of Oxford has reported that people who had received three doses of Pfizer’s original COVID vaccine produce fewer antibodies in response to BA.4.6 than to BA.4 or BA.5. This is worrying because it suggests that COVID vaccines might be less effective against BA.4.6. The emergence of BA.4.6 and other new variants is concerning. But vaccination continues to offer good protection against severe disease, and is still the best weapon we have to fight COVID.
Vaccination is key
The emergence of BA.4.6 and other new variants is concerning. It shows the virus is still very much with us, and is mutating to find new ways to overcome our immune response from vaccination and previous infections.
We know people who have had COVID previously can contract the virus again, and this has been particularly true of omicron.
But vaccination continues to offer good protection against severe disease, and is still the best weapon we have to fight COVID. The recent approval of bivalent boosters is good news. Beyond this, developing multivalent coronavirus vaccines that target multiple variants could provide even more durable protection.
A recent study showed that a multivalent coronavirus vaccine administered through the nose elicited a strong immune response against the original strain of SARS-CoV-2, as well as two variants of concern, in mouse models.
Close monitoring of new variants including BA.4.6 is pressing, as they could lead to the next wave of COVID pandemic. For the public, it will pay to stay cautious, and comply with any public health measures in place to prevent the spread of what remains a very contagious virus.
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